Medications for Narcolepsy.

Medications for Narcolepsy.

Medications for Narcolepsy.

Stimulants: Drugs which stimulate the central nervous system are the main treatment to help people with narcolepsy stay awake during the day. Modafinil (Provigil), a newer stimulant, is not as addictive and does not produce the highs and lows often associated with older stimulants.


Antidepressants: These suppress REM sleep, help alleviate the symptoms of cataplexy, hypnagogic hallucinations and sleep paralysis.

Sodium oxybate (Xyrem): This controls cataplexy in people with narcolepsy. Sodium oxybate helps to improve nighttime sleep, which is often poor in narcolepsy. In high doses it may also help control daytime sleepiness, even though you take it only at night.

Modafinil (Provigil, Cephalon) Modafinil is a new well tolerated and effective medication for narcolepsy patients. It promotes alertness, in the same way that traditional stimulants have done but withoutthe negative side effects common to stimulant therapy. It also tends to have a longer lasting effect. In fact this new drug is first choicefor all newly diagnosed narcolepsy patients or for those people who are bothered by negative side effects from the older medications.It can be prescribed alongside traditional stimulants if necessary.

Traditional stimulantsThese include methylphenidate and dextroamphetamine. Other amphetamines, amphetamine-analog agents, and sustained-release preparations are available. Many people experience negative effects with these stimulants. It also may aggravate sleepiness ( rebound hypersomnia) as the dose wears off. Also a tolerance may develop (tachyphylaxis) to the alerting effect in cases of repeated dosing. AmphetaminesWhile amphetamines are often used totreat narcolepsy and are generally very effective they do carry the following side effects of headache, gastrointestinal disturbance, anxiety, irritability, increased pulse, and increased blood pressure

Methylphenidate This is also generally effective but carries the same side effects as above. However they tend to be milder than in the case of amphetamines.

Pemoline (Cylert. Abbott)This is less effective in maintaining daytime alertnessthanmethylphenidate, dextroamphetamine, or methamphetamine. Pemoline may also lead tohepatotoxicity. It is generally a second or third-line agent which if used must be accompanied by regular liver function checks due to its potential for hepatic failure. However its side effects are milder than those of amphetamines.

Mazindol This is considered a less effective stimulant. Theusual initial dose is 1-2 mg once or twice daily with a maximal dose of 8 mg in divided doses. All higher doses are carefully monitored.

Before using any of the stated medications for Narcolepsy,seek medical consent.
Return From Medications for Narcolepsy to Narcolepsy Index.


Sleeping Disorders Homepage.




Melatonin and Hair Loss Melatonin and Hair LossHow Melatonin can help regrowyour hair or change it's coloring.Melatonin and Hair Lossand Gain has become the center of MelatoninResearch in recent times. There isnow evidence to prove that melatonindirectly affects hair growth and loss. Melatoninis a hormoneproduce in your body by the pineal gland. Thi...

Questions QuestionsSearch the topics below to find answers to some of our frequently asked questions. You may find an answer to a question that you have!ABOUT SLEEPHow do I fall asleep faster and stay asleep longer?Need help for night sweats and insomniaFree music to help you sleepCHILDRENHow to help my 10 month old fall asleep by herselfWhy can't m...

Melatonin and Sleep Problems, Patterns andDisturbances. Melatonin and Sleep Problems, Patterns andDisturbances.Melatonin and Sleep Improvement;This page contains all you will ever need to know on dosage, overdose, side effects, drug interactions, benefits and information how to take melatonin. The rate of production of melatoninin the human body is ...

This Page on Sleep Apnea in Infants Symptoms is the concluding part of Sleep Apnea in Infants page. Start reading from there to get the full article. Now let's talk about Sleep Apnea in Infants Symptoms....