Melatonin and Drug Interactions

Melatonin and Drug Interactions

Melatonin and Drug Interactions is a hot topic and I set up this page to tackle this issue.

Melatonin is one of the gentlest supplements,out there that you couldingest. It comes with little or no side effect andeven in cases ofmelatonin over dose, the effect is minimal.

There is the issue though of melatonin and drug interactions. Adrug interaction issimply when the ingestion of a drug reacts withanother drug or with yoursystem to produce a hazardous side effects.

Not all drugs would trigger a reaction with melatoninsupplements,as melatonin occurs naturally in the brain. In case youare onmedication and you want to find out what drugs can possibly react with melatoninand have side effects in your body, this page should answer anyquestion you have.


Melatoninand Drug Interactions.
Melatonin supplement is used to balance yoursleep cycle rhythm when it is out of order.This could happen because of jetlag or working shifts. Based on thisfact, it is not advised to combinemelatonin supplements and sedativesas it may cause heavy drowsiness. My adviceis that you should stayaway from heavy machinery or driving if you feeldrowsy.


DiabeticDrugs.
Melatonin supplements have the potential toincrease your blood sugarwhile diabetic medications are used to lower yourblood sugar level.When these two are combined, the diabetic drugs will havelittle or noeffect.


Immunosuppressant.
Adequatesleep is good to help the bodyboost its immune system and melatoninsupplements can help your sleep cyclereadjust to its normal state whenit has been altered. Immunosuppressant drugsare used by thosesuffering from immune system disorders like systemic lupuserythematosus and rheumatoidarthritis. Combining these drugs withmelatonin would make them ineffectiveas melatonin has the tendency toincrease the strength of your immune system.


Anticoagulants.
Anticoagulants have also been found tointeract with melatonin asmelatonin slows down the process of blood clotting.Taking melatoninwith anticoagulants increases the chances of less blot clotduringbleeding.


Anti-Depressants.
Peopleusing antidepressants have also beencautioned against the use ofmelatonin as adequate information has not beengathered about it’sinteraction with melatonin. Few studies have only reportedthat somepeople complained of serious drowsiness, confusion, memory loss,breathing difficulties, itching and vomiting the day after, due to thefactthat antidepressants already increases the level of melatoninproduction by thebody.


Pregnant women or people trying to getpregnant are also advised to stay away from melatonin supplements as they mighthave a birth control effect. Research is still in progress to find outif melatoninsupplements might have any effect on the expected baby.


Breastfeeding mothers should be alsocautious about melatonin and arebeen advised to talk to their doctors abouttaking melatoninsupplements as their sleep cycle could be altered during thefirst 3months.


If you take alcohol or drugs or even caffeine,itis advisable to stay away from melatonin as it might cause headaches andalso cause a altered sleep pattern.

 

Here is a list of Melatonin and Drug Interactions.


Antipsychotic Drugs:
Aripiprazle (Abilify), Chlrprmazine(Thrazine), Clzapine (Clzaril,FazaCl), Fluphenazine (Prlixin) lanzapine (Zyprexa, Symbyax),Perphenazine (Trilafn),Paliperidne (Invega) ,Quetiapine ,(Serquel),Risperidne(Risperdal), Thiridazine (Mellaril),Trifluperazine(Stelazine), Ziprasidne (Gedn)


Barbiturates:
Amobarbital (Amyta), Butalbital (Fioricet,Fiorinal), Pentobarbital(Nembutal), Phenobarbital(Luminal), Secobarbital(Seconal).


Benzodiazepines(Sedatives)
Alprazlam (Xanax, Xanax XR), Chlrdiazepxide(Librium, Limbitrl,Librax), Clnazepam (Klnpin)Clrazepate (Tranxene) ,Diazepam(Valium),Estazlam (PrSm), Flurazepam(Dalmane) ,Lrazepam (Ativan),Midazlam(Versed),Temazepam (Restril), Triazlam(Halcin), clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal),zolpidem (Ambien).


Antidepressants:
Amitriptyline (Elavil)Amoxapine(Asendin)Bupropion (Budeprion XL, Budeprion™ SR, Buproban™, Wellbutrin SR,Wellbutrin XL,Wellbutrin, Zyban)Citalopram (Celexa)Clomipramine(Anafranil)Desipramine (Norpramin)Desvenlafaxine (Pristiq™)Doxepin(Sinequan)Duloxetine (Cymbalta)Escitalopram (Lexapro)Fluoxetine (Prozac,Sarafem, Selfemra™)Fluvoxamine (Luvox, Luvox CR)Imipraminehydrochloride(Tofranil)Imipramine pamoate (Tofranil PM)Isocarboxazid(Marplan)Maprotiline(Ludiomil)Mirtazapine (Remeron)Nefazodone(Serzone)Nortriptyline(Pamelor)Paroxetine (Paxil, Paxil CR, Pexeva)Phenelzine (Nardil)Protriptyline(Vivactil)Selegiline (Emsam)Sertraline (Zoloft)Tranylcypromine (Parnate)Trazodone (Desyrel).Trimipramine (Surmontil) Venlafaxine (Effexor,Effexor XR).


Calcium channel blockers:
Amlodipine (Norvasc),Diltiazem (Cardizem,Cardizem CD, Cardizem LA,Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Dilt-XR,Taztia XT,Tiazac),Felodipine (Plendil),Isradipine (Dynacirc, DynacircCR),Nisoldipine (Sular),Nicardipine (Cardene, Cardene SR),Nifedipine(AdalatCC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia,Procardia XL),Nimodipine (Nimotop)


DiabeticDrugs:
glimepiride (Amaryl), glyburide (DiaBeta,Glynase PresTab,Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia),chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide(Orinase).


Immunosuppressants.
azathioprine (Imuran), basiliximab(Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus(FK506, Prograf), sirolimus (Rapamune),prednisone (Deltasone, Orasone),corticosteroids (glucocorticoids).


Anticoagulants:
aspirin, clopidogrel (Plavix), diclofenac(Voltaren, Cataflam,others), ibuprofen (Advil, Motrin, others), naproxen(Anaprox,Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox),heparin,warfarin (Coumadin, Jantoven).


If your medication is listed above I wouldadvise you try some other overthe counter sleep aid or see your doctor for a proper consult.

More information on melatonin and drug interactions or melatonin supplements?Check my melatoninsupplements page.

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